বুধবার, ৯ মে, ২০১২

SWAC Girl: Teacher Appreciation Week 2012

To teach is to touch the future. In honor of Teacher Appreciation Week running May 7-11, 2012, why not take a moment to thank your children's teachers, or to remember those who made a difference in your own life.

This big red apple is for my sister who is in the Chesterfield County, Va, school system teaching elementary students, for all my teacher friends, for the homeschool moms who are 24/7 teachers, and for those educators who helped mold me.

I was educated in the Chesterfield County public school system outside Richmond. I received a wonderful education, and there are teachers from elementary through high school who still stand out to me.

Mrs. Gibson was my first grade teacher, a loving lady whose daughter was my best friend (and who is now a pharmacist). Mrs. Gibson taught me to read and opened the world to this bookworm.

Mrs. Booth was my sixth grade teacher who encouraged my love of writing and who hoped to see me published one day. When The Washington Examiner offered a paid writing position several years ago, Mrs. Booth's hope from years earlier finally came true.

In seventh grade I had Mr. Witthoeft, a teacher fresh out of college who was youthful and fun. We were in middle school but weren't to the point of changing classes yet so he was my sole teacher for all subjects. What a class of high achievers we had!

What Mr. Witthoeft did was continue to encourage my love of writing as well as compliment my love of reading. He once asked the class how many books they read each month. When he got to me, he filled in the blank himself: "Probably 30 or so." That was a bit of an exaggeration but he had noticed that I always had a book in my hand.

He taught creative writing in a way that made me want to jump into the assignments. Math? Ugh. Writing? Bring it on! It kindled the fire that still burns inside to write and share in what is a cathartic activity for me.

Another budding writer was in that class and he made newspaper reporting his career. Even today, Bob Stuart's articles -- many about politics -- can be read in the Waynesboro News Virginian. Oddly enough, after parting ways at the completion of high school, he and I have now lived in the same area of the Shenandoah Valley for a number of years and often see one another at supervisor meetings and other news-worthy events.

In high school there was an older gentleman whose name I cannot dredge up at the moment but he was the teacher instrumental in bringing debating into my life. Every issue has (at least) two sides, and he taught us to research and use facts instead of getting caught up in the passion of hysterics. He wasn't able to teach me to be comfortable with public speaking -- I still took zeros on any subject that required standing in front of the class -- but I learned to use those debate skills in my writing.

Years later when I was in my 40s, after spending years educating my children at home, I? finally overcame my fear of public speaking with the help of a homeschool student. Nate Salatin, who spoke frequently for Augusta County 4-H projects, taught a public speaking class in my living room for his fellow homeschool students. I took the class right along with them. Nate provided the tools necessary to become comfortable addressing crowds, and I later went on to speak at his Class of 2007 graduation as well as at conventions and other venues. I looked forward to speaking and learned to enjoy this mid-life achievement.

Even today I'm still learning from those around me especially the youthful bloggers who offer technical advice and open my eyes to new worlds of technology. My teacher friends encouragingly push me beyond my comfort zone as I continue my learning journey.

To them all, I tip my hat with gratitude for the hours of dedication, energy, and loving attention they put into making education fun and, well, educational, for their students because to teach is, truly, to touch the future.

Cross-posted at Bearing Drift

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Derby winner checks into Pimlico for Preakness

Kentucky Derby winner I'll Have Another reaches for horse therapist Tyler Cerin from a stable at Pimlico Race Course in Baltimore, Monday, May 7, 2012. I'll Have Another is expected to compete in Baltimore's Preakness Stakes horse race on May 19. (AP Photo/Patrick Semansky)

Kentucky Derby winner I'll Have Another reaches for horse therapist Tyler Cerin from a stable at Pimlico Race Course in Baltimore, Monday, May 7, 2012. I'll Have Another is expected to compete in Baltimore's Preakness Stakes horse race on May 19. (AP Photo/Patrick Semansky)

Horse therapist Tyler Cerin looks after Kentucky Derby winner I'll Have Another after arriving at Pimlico Race Course in Baltimore, Monday, May 7, 2012. I'll Have Another is expected to compete in Baltimore's Preakness Stakes horse race on May 19. (AP Photo/Patrick Semansky)

Kentucky Derby winner I'll Have Another stands in a stable at Pimlico Race Course in Baltimore, Monday, May 7, 2012. I'll Have Another is expected to compete in Baltimore's Preakness Stakes horse race on May 19. (AP Photo/Patrick Semansky)

Kentucky Derby winner I'll Have Another is led out of a trailer by foreman Benjamin Perez after arriving at Pimlico Race Course in Baltimore, Monday, May 7, 2012. I'll Have Another is expected to compete in the Preakness Stakes horse race in Baltimore on May 19. (AP Photo/Patrick Semansky)

BALTIMORE (AP) ? Kentucky Derby winner I'll Have Another evidently loves traveling every bit as much as galloping on the track.

The chestnut colt arrived at Pimlico Race Course on Monday after being taken by charter plane from Kentucky to Baltimore. After the plane touched down, I'll Have Another and five of his stable mates received a police escort from Baltimore-Washington International Airport to Pimlico, site of the Preakness on May 19.

"He loves to fly. His ears were pricked," assistant trainer Jack Sisterson said. "We were getting a police escort and there were people in the streets chanting, 'I'd love another.' He knows that's him. His ears were pricked and he's bobbing his head, going, 'Yeah, that's me.'"

I'll Have Another trainer Doug O'Neill had business in California, so Sisterson accompanied I'll Have Another from Louisville.

It's the earliest arrival by a Derby winner since Monarchos was shipped just four days after his 2001 victory.

"We discussed a few plans and we just thought the more time here to get used to the surface, the better for him," Sisterson said. "Every trainer has a different training style. I suppose it's better to get the horse used to the surface and things like that. So, he's here now, and we're excited to have him here for the two weeks."

Instead of staying in Stall 40, the traditional Pimlico home of the Derby winner, I'll Have Another was guided by groom Benjamin Perez into Stall 17 in Barn D ? next to the Preakness Stakes barn. He is positioned between two other horses trained by O'Neill.

For Team O'Neill, serenity was more important than tradition.

"I suppose it's like a human. You want to try and get your rest," Sisterson said. "If you've got 50 million people outside your bedroom, stopping and peeking every single day, you wouldn't get much sleep, would you? I suppose being out of the way, getting him to relax and being himself, is better for the horse."

I'll Have Another won the Kentucky Derby as a 15-1 shot and became the first horse ever to win the Derby from the 19th post.

Now he's got a shot at becoming horse racing's first Triple Crown winner since Affirmed in 1978.

Sisterson said the team began thinking about the Preakness soon after the conclusion of the Derby.

"I suppose when you cross the winning line in first position, you're, 'Wow, we're off to the Preakness now,'" Sisterson said. "Obviously you don't want to jump ahead of yourself. You want to see how he comes out of the race and things like that. He's doing fantastic. He's eating everything."

Those around I'll Have Another couldn't be happier.

"An absolute dream come true," Sisterson said. "Words can't describe the feeling. We're excited about the horse."

Associated Press

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মঙ্গলবার, ৮ মে, ২০১২

'The Voice' crowns second-season champion

FILE - In this Oct. 28, 2011 file photo, from left, judge Blake Shelton, host Carson Daly, judge Christina Aguilera, producer Mark Burnett, judge Cee Lo Green, and judge Adam Levine, from the "The Voice", pose for photographers in Culver City, Calif. The season two winner of the singing competition series will be revealed on Tuesday, May 8, on a live finale airing at 9:00 p.m. EST on NBC. (AP Photo/Matt Sayles, file)

FILE - In this Oct. 28, 2011 file photo, from left, judge Blake Shelton, host Carson Daly, judge Christina Aguilera, producer Mark Burnett, judge Cee Lo Green, and judge Adam Levine, from the "The Voice", pose for photographers in Culver City, Calif. The season two winner of the singing competition series will be revealed on Tuesday, May 8, on a live finale airing at 9:00 p.m. EST on NBC. (AP Photo/Matt Sayles, file)

LOS ANGELES (AP) ? Jermaine Paul was front and center on "The Voice."

The 33-year-old background singer from Harriman, N.Y., was declared the winner of the NBC singing competition Tuesday.

Paul, who was coached by country singer and "Voice" mentor Blake Shelton, was awarded the show's grand prize of $100,000 and a record deal with Universal after crooning R. Kelly's "I Believe I Can Fly" for his final solo performance Monday.

"I just want to say thank you to everybody that supported me from day one," said Paul through tears.

Juliet Simms, the 26-year-old indie rocker from San Francisco who was coached by Cee Lo Green, came in second place. She was followed by Tony Lucca, the 36-year-old former Mouseketeer from Detroit, who was guided by Maroon 5 frontman Adam Levine. Chris Mann, the 30-year-old classical singer from Wichita, Kan., who was shepherded by pop diva Christina Aguilera, rounded out the final four.

Javier Colon won the first season of "The Voice" last year.

___

Follow AP Entertainment Writer Derrik J. Lang on Twitter at http://www.twitter.com/derrikjlang .

___

Online:

http://www.nbc.com/the-voice

Associated Press

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Stretch It Out: 10 Extreme Limos

England-based Prestige Limousine created the first-ever 400-hp Ferrari F1 360 limousine by adding nonstructural carbon-fiber panels bonded to the existing Ferrari. The designers worried about adding the extra weight to the vehicle, but reinforced the added section with even more carbon fiber. The best part? Enormous Ferrari-red gullwing doors.

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Can 'Dark Knight Rises' Beat 'The Avengers' Debut?

The Weekly Rising investigates how the superhero box-office returns will measure up.
By Kevin P. Sullivan


Christian Bale on the set of "The Dark Knight Rises"
Photo: Getty Images

In the battle of the summer superhero blockbusters, journalists and box-office analysts pitched the story as "The Avengers" versus "The Dark Knight Rises." Could Marvel's crazy experiment pay off? Would it be enough to stop Batman from owning the box office once again? Most had "The Dark Knight Rises" pegged to repeat the magic that was 2008's "The Dark Knight" and the phenomenon that followed, but that was before this past weekend.

When the underdog in a war for box-office supremacy takes in $207.1 million during its opening weekend, the tide tends to shift in its favor. As soon as "The Avengers" finished its record-smashing debut, "The Dark Knight Rises" became the underdog, a shoo-in for second place.

But what happened to seemingly damn Christopher Nolan's final Batman movie to runner-up status?

The Dark Knight
When the follow-up to "Batman Begins" hit theaters in July 2008, it was a cultural event. Not only had expectations been so high for the sequel of the first great Batman movie, but the introduction of the Joker and Heath Ledger's untimely passing made the film a must-watch. Everyone was talking about it. Not only had it captured the world's headlines, but critics praised it as something more than a superhero movie. It was the perfect storm of movie buildup. Thankfully, tragedy has not struck the release of "The Dark Knight Rises," but without the headlines, it doesn't have as much momentum as its predecessor did heading into July.

"The Avengers" Is New
People have simply never seen superheroes from different films come together to fight in a single crossover movie. That's something new, and new will always sell. While that isn't to say that "The Dark Knight Rises" isn't new, it certainly doesn't mix up the superhero genre as much as "The Avengers." Comparing the two isn't even necessarily a fair fight. Marvel had the audience invest in five movies over the course of four years, eventually leading up to an ultimate sequel for each separate franchise. Two previous Nolan films exist and came out over the course of seven years. Checking out "The Avengers" simply has a higher return rate.

3-D
The surcharge for the added dimension will likely be the death knell for "The Dark Knight Rises." Each filled seat for "The Avengers" in 3-D is an automatic advantage. This seems especially significant when you learn that 3-D screenings accounted for 52 percent of the opening-weekend gross for Marvel and Disney. The added fee was also a strong factor in driving "Harry Potter and the Deathly Hallows, Part 2" to its then-record total.

Fun
Despite both being "superhero movies," "The Avengers" and "The Dark Knight Rises" are two very different films. As I discussed in last week's column, though the films feature crime fighters, they strike very different tones and attempt two very different things. "The Avengers" had crowds cheering in triumph. Its humor became an essential part of its overall entertainment value. Nolan's Batman trilogy has thus far gone for something very different. They comment on current events. There isn't always a happy ending, usually at best the glimmer of hope. "The Dark Knight Rises" may be a film people return to over a long box-office run, but "The Avengers" is the one they turn out in droves for.

Why That's OK
But here's the kicker: None of this really matters. Both films earned or will earn all our salaries just minutes after their midnight releases, and their profitability was never really in question. Christopher Nolan will work again. Joss Whedon even healed some of the "John Carter" wounds at Disney. All that matters is that we will get to see both within a few months of each other. With that in mind, how much is there really to worry about?

Which movie do you think will come out on top? Let us know in the comments below or tweet me @KPSull!

Check out everything we've got on "The Dark Knight Rises."

For breaking news and previews of the latest comic book movies — updated around the clock — visit SplashPage.MTV.com.

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Heart attack survivors living close to highways face higher 10-year death risk

ScienceDaily (May 7, 2012) ? Living close to a major highway poses a significant risk to heart attack survivors, reinforcing the need to isolate housing developments from heavy traffic areas, a Beth Israel Deaconess Medical Center study concludes.

Writing in the May 7 edition of Circulation, researchers found heart attack survivors living less than 100 meters or 328 feet from a roadway have a 27 percent higher risk of over within 10 years than survivors living at least 1,000 meters away. That risk recedes to 13 percent for those living between 200 and 1,000-meter or 656 to 3,277-feet from the roadway.

"Living close to a highway is associated with adverse cardiovascular outcomes in those with underlying cardiac disease," says Murray Mittleman, MD, DrPH, a physician in the CardioVascular Institute at Beth Israel Deaconess Medical Center, an Associate Professor of Medicine at Harvard Medical School and director of BIDMC's cardiovascular epidemiological research program. "Besides air pollution, exposure to noise could be a possible mechanism underlying this association."

The Onset study of 3,547 heart attack survivors in 64 community hospitals and tertiary care medical centers recorded 1,071 deaths over 10 years. Of that total, 63 percent of the patients died of cardiovascular disease, 12 percent died of cancer and 4 percent expired from respiratory disease. Researchers analyzed factors such as personal, clinical and neighborhood-level characteristics such as income and education.

"People with lower levels of education and income are more likely to live in communities closer to a major roadway, so they are bearing a larger burden of the risk associated with exposure than people with more resources," says Mittleman.

In a study published earlier this year, a team led by Mittleman found air pollution, even at levels generally considered safe by federal regulations, increases the risk of stroke by 34 percent. Exposure to ambient fine particulate matter, generally from vehicle traffic, was associated with a significantly higher risk of ischemic strokes on days when the EPA's air quality index for particulate matter was yellow instead of green.

These finding provide new evidence that long-term exposure to roadways is associated with an increased risk of death in patients with underlying cardiovascular disease.

"Clinicians need to educate their patients on the risks posed by particulate matter pollution and encourage patients with cardiovascular disease to avoid unnecessary exposure to traffic," says Mittleman.

"On a public policy level, city planners should consider locating housing developments away from the most heavily trafficked roadways."

"This study adds to the growing knowledge linking roadways and traffic to health problems, even death, especially among those with pre-existent disease -- in this case a previous heart attack," says Dan Costa, ScD, DABT, National Program Director for Air Climate & Energy Research in U.S. Environmental Protection Agency Office of Research and Development Research.

In addition to Mittleman, co-authors include Joshua I. Rosenbloom, MPH, Elizabeth H. Wilker ScD, of the BIDMC Cardiovascular Epidemiological Research Unit; Kenneth J. Mukamal MD. MPH of BIDMC's Division of General Medicine and Primary Care; and Joel Schwartz, PhD of the Harvard School of Public Health.

The study was funded by the US Environmental Protection Agency and the National Institute of Environmental Health Science. Wilker was supported by a grant from the National Institutes of Health and Rosenbloom was supported by the Harvard Medical School Scholars in Medicine Office.

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Story Source:

The above story is reprinted from materials provided by Beth Israel Deaconess Medical Center, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Joshua I. Rosenbloom, Elissa H. Wilker, Kenneth J. Mukamal, Joel Schwartz, Murray A. Mittleman. Residential Proximity to Major Roadway and 10-Year All-Cause Mortality After Myocardial Infarction. Circulation, 2012; 125: 2197-2203 DOI: 10.1161/CIRCULATIONAHA.111.085811

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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Matthew Fox Arrested for Drunk Driving


Matthew Fox has run into more problems with the law and with alcohol.

About nine months after allegedly attacking a female bus driver in a drunken rage, the former Lost star was arrested for DUI in Oregon on Friday.

Matthew Fox, Margherita Ronchi

Police sources tell TMZ that Fox was booked at 3:23 a.m. local time, taken into custody and released later that day. Not many other details are available, but a passenger was reportedly in the car as well.

Fox, who lives in the local city of Bend, was on his way to a fast food joint for a very late-night bite, insiders tell the site.

[Photo: Pacific Coast News]

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Polish Architects Build Stereotype-Reinforcing Upside-Down House [Video]

With a last name like Liszewski, I've heard every single Polish joke and stereotype there is. But I'm going to assume that Polish architects Irek Glowacki and Marek Rozanski have just spawned at least one more with this unique tourist attraction they built in Austria. More »


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Blackburn chief wanted Kean out - report

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Justin Bieber?s ?Boyfriend? video hits more than 12m views, Shakira?s ?Addicted To You? passes 4m

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Indian leader can be tried over anti-Muslim riots: report

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Disrupt NYC Hackathon ? More Details

Disrupt NYC HackathonWe’re less than two weeks away from 24 hours of sheer hacking bliss. We’ve also released the final batch of tickets for the event, so if you’re planning on hacking, this is your final chance to get tickets. http://tcdisruptny-hackathon2012.eventbrite.com/ Developers looking to find a group to hack with, toss your hat in the ring at:?http://bit.ly/nyc-disrupt-collab. Likewise, if you’re a designer looking to find a team for the event, add your details to the Design Trust form at:?http://bit.ly/nyc-disrupt-dt New API Workshop Sessions We’ve added another lecture area to allow for a whole new batch of great API workshops. Microsoft – 2pm Presenter:?Danilo Diaz,?Microsoft Developer Evangelist where he helps developers understand Microsoft’s product offerings and strategy. Come learn more about the award winning Windows Phone platform and how to make your apps come alive on it! You?ll hear more from Developer Evangelist Dani Diaz on how to build beautiful apps on Windows Phone. To get yourself prepared, you should review the Windows Phone Training & Download Windows Phone Tools SDK Mashery – 3pm Presenter:?Amit Jotwani,?Developer Advocate & Front-end Developer at Mashery Mashery is the world leader in API technology and services helping over 150 companies manage their APIs. “Read Less, do more” is the mantra of this workshop. Developers will get a taste of API Explorer – an interactive documentation system designed to learn and explore RESTful APIs like Klout, USA TODAY, Rovi, Whit.li, NY Times and many more. Hacks built using any APIs listed in our API Explorer would be eligible for Mashery prize. Additionally, we’d be giving out beer-opening USB drives with code libraries and tools from our Mashery Hack Shortcut station onsite. Details regarding Mashery’s API can be found at:?http://dev.mashery.com/iodocs CityGrid – 4pm Presenter:?Kin Lane,?Developer Evangelist for CityGrid Monetize your local web and mobile applications using CityGrid. Local advertising is expected to grow 18% from $15.7 billion this year to $18.5 billion according to Borrell & Associates. Local advertising is a primary way for developers to monetize their web and mobile apps. Learn how to monetize your apps with CityGrid mobile, web, or custom advertising APIs and Places that Pay. Developers can earn revenue from just displaying information about certain businesses and connecting users with merchants via reviews, offers, images, videos, social networks and on the phone. Understand how to maximize your applications revenue with local advertising, but also go beyond advertising by delivering valuable content to your users,

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Wills, Trusts & Estates Prof Blog: Lock and Load: Put Your Guns In A ...

? Courtney Love Has Lost Rights To Cobain's Image | Main | RPTE Fellowships -- Applications Available ?

May 7, 2012

Lock and Load: Put Your Guns In A Gun Trust

America!David Goldman (Attorney at Law, Apple Law Firm PLLC) posted a blog on the?Florida Estate Planning Lawyer Blog?about an an article he?published entitled, A New Breed of Gun Trusts - Protecting Firearms Collectors & Their Collections, Ammoland, Apr. 30, 2012. The introduction to his article is provided below:

The topic of estate planning is not usually met with joyous optimism.

It conjures thoughts of the after life, financial planning, and lots of paperwork.

For these reasons, people often avoid the estate planning process altogether. No bigger mistake can be made, as the ease of creating estate planning documents and the protection they can afford are unparalleled.

With the help of a Gun Trust and Estate Planning attorney, the options are endless when it comes to protecting your firearms. Traditional estate planning can be problematic when dealing with firearms, because the documents used to manage your bank accounts often instruct people to violate laws when applied to the transfer, possession, and use of firearms. A Gun Trust is an estate planning document that has been designed to help you acquire, manage, use, and transfer firearms including those restricted by the NFA while protecting your family and friends from inadvertent violations of state and federal laws.

May 7, 2012 in Articles, Current Affairs, Non-Probate Assets, Trusts | Permalink

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Education secretary says he backs same-sex marraige

Carolyn Kaster / AP

Education Secretary Arne Duncan

Vice President Joe Biden's declaration Sunday on "Meet the Press" that he's "absolutely comfortable" with gay marriage continued to reverberate Monday.

On Morning Joe, U.S. Secretary of Education Arne Duncan echoed Biden. Asked by TIME's Mark Halperin whether he thinks same-sex couples should be legally allowed to marry, Duncan said flatly: "Yes I do."

"Have you ever said that publicly before?," Halperin wondered.

"I don?t think I?ve ever been asked publicly," Duncan replied.

Forty-nine percent of Americans agree with Duncan and Biden on the issue, according to recent polling. That number has risen sharply in recent years.

The Morning Joe panel contrasted Biden and Duncan's stance with that of their boss, President Obama, who does not favor same-sex marriage, but has said his views are "evolving."


That's not enough for many backers of gay marriage, though. Before Duncan's appearance, the Morning Joe gang was joined by Politico's Jim VandeHei, who said the gay-rights community is frustrated that Obama hasn't yet come out in full-throated support for what they call marriage equality.

"They want him to come out and unequivocally state that he?s for gay marriage," said VandeHei. "And that?s why there?s been frustration from gay-rights activists since the beginning of the administration."

Most observers think Obama personally has no problem with same-sex nuptials. So why won't he take the leap, asked Willie Geist?

VandeHei admitted to being stumped. "I don?t really think that the politics are that tricky for him any more," he said.

But Joe Scarborough said the president likely has his eye on southern swing states like Virginia and North Carolina, where backing gay marriage could motivate social conservatives to turn out in droves against him. "You want to engage conservative Democrats, conservative independents, conservative Republicans?" asked Scarborough. "Then put this out there."

Halperin agreed, and said it's not just the south. "I would add Ohio to that list," he said. "And Wisconsin, and maybe Iowa."

Watch the clip below:

?

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Polar Opposites (talking-points-memo)

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Sloppy shipping of human retina leads researchers to discover new treatment path for eye disease

Sloppy shipping of human retina leads researchers to discover new treatment path for eye disease

Saturday, May 5, 2012

Sloppy shipping of a donated human retina to an Indiana University researcher studying a leading cause of vision loss has inadvertently helped uncover a previously undetected mechanism causing the disease. The discovery has led researchers to urge review of how millions of dollars are spent investigating the cause of a type of age-related macular degeneration called choroidal neovascularization.

Working at IU's Biocomplexity Institute, postdoctoral researcher Abbas Shirinifard had hit a brick wall trying to develop detailed computer simulations of the behaviors and interactions of the cells and membranes composing the rear of the retina and its supporting vasculature. In choroidal neovascularization (CNV), blood vessels that supply the eye with oxygen and nutrients and originate in the choroid just behind the eye abruptly break into the retina and disrupt it. Blindness can follow in a matter of months.

Two current treatments for CNV either kill the invading blood vessels with drugs injected into the eye (also damaging the retina and killing needed blood vessels as well) or laser-heat the blood vessels, which can cause damaging retinal scars. Yet with 9,000 research papers published on CNV over the past 10 years, neither treatment still addresses the underlying problems that cause the blood vessels to invade, so relapses are common and many patients still lose vision within a year or two.

A serendipitous accident in which a donated human retina from an eye bank was severely shaken during shipping inspired Shirinifard to try again with a series of new simulations. Upon examination of the eye, Shirinifard and Biocomplexity Institute senior microscopist Sherry Clendenon found that regions of the retina with invading blood vessels had separated from their underlying membrane, while regions that had stayed attached showed much less invasion, suggesting that adhesion might be an essential but overlooked mechanism in maintaining the retina's structure.

Using an open-source modeling software program called CompuCell3D developed by the Biocomplexity Institute in collaboration with the University of Washington and the University of Wisconsin under National Institutes of Health funding, the team quickly began extending existing simulations to study the effects of adhesion defects.

"The simulations showed that reduced adhesion in the retina could indeed lead to its invasion by blood vessels," Shirinifard said. "But the complex structure of the retina meant that many types of adhesion could be important -- the three most prominent being between the pigmented retinal cells (the black lining of the eye) and Bruch's membrane (the substrate that supports the retina), between adjacent pigmented retinal cells, and between pigmented retinal cells and the overlying photoreceptors."

Those variables, the team realized, could be independent of one another or interact in complex ways, and knowing that the rate and type of progression of the disease varies greatly from patient to patient, they needed to examine many examples of each adhesion combination.

That's when Quarry, the IU computer cluster operated by the Office of the Vice President for Information Technology, was called in to push out 32,000 hours of calculations.

"We were able to model the interactions of different degrees of impairment of each type of adhesion and the variation from case to case," Shirinifard said. "Amazingly, these simulations were able to replicate the complex spectrum of CNV seen in the clinic."

Simulations of adhesion defects caused by reduced adhesion between pigmented retinal cells and Bruch's membrane -- the type of CNV typical of aging -- produced a pattern and frequency of invasion agreeing with that in the clinic. Similarly, reduced adhesion between neighboring pigmented retinal cells, typical of inflammation due to severe infection, produced a pattern of invasion agreeing with that seen in young adults.

By combining thousands of simulations, Shirinifard was able to produce maps that related defects in each type of adhesion to the risk of each type of invasion. In turn, he could show that cell adhesion is key to keeping blood vessels out of the retina and that combination defects in the different types of adhesion are sufficient to determine the probability, pattern and rate of progression of CNV.

The full results of one of the most complex tissue evolution models ever deployed were published today in PLoS Computational Biology, and while the team has yet to move toward developing new CNV therapies, the work should have great significance in the search for better therapies, according to Biocomplexity Institute Director James Alexander Glazier, a co-author on the paper and professor in the IU Bloomington College of Arts and Sciences' Department of Physics.

"Hundreds of millions of dollars are spent annually to develop drugs and treatment approaches based on the two commonly hypothesized CNV initiation and progression mechanisms," he said. "Because the current work shows that neither hypothesized mechanism is an important cause of CNV, that money and effort are extremely unlikely to improve outcomes for patients. Scientists have been barking up the wrong tree. Instead, a search for therapies which restore normal adhesion in the eye is much more likely to produce effective treatments. In addition, the detailed agreement between simulation and clinical observations suggests that new approaches to measuring adhesion in patients would allow much more accurate predictions of the prognosis for individual patients."

The researchers believe these results will also have a much broader impact, as they apply to any tissue -- like the gut and the lung -- in which a basement membrane separates a capillary network from a nearby epithelium.

"The relationships between specific classes of adhesion failures and the types and dynamics of CNV in the eye simulations should carry over to the neovascularization-dependent pathologies of those tissues and to invasion of those tissues in cancer progression," Shirinifard said.

###

Indiana University: http://newsinfo.iu.edu

Thanks to Indiana University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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New video of Australian kidnapped in Philippines

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Yahoo shareholder demands records on CEO's hiring

Third Point begins process of obtaining records relating to Yahoo CEO Scott Thompson's hiring, reports CNBC's Kate Kelly.

By msnbc.com news services

A major Yahoo (YHOO) shareholder has made a legal demand for internal records about the embattled Internet company's hiring of CEO Scott Thompson.?

Activist hedge fund Third Point LLC took the unusual step Monday as part of its effort to oust Thompson for an inaccuracy about his academic credentials. ?

Shares of Yahoo were up slightly in midday trading.?

After exposing the fabrication last week, Third Point set a noon Eastern Time deadline Monday for Yahoo to fire Thompson for unethical conduct. That deadline passed without any change in Thompson's status.?

Third Point wants to review Yahoo Inc. documents that may explain how much research the company's board did about Thompson before hiring him in January. The fund contends it's entitled to the records under the laws of Delaware, where Yahoo is incorporated.

Yahoo didn't immediately respond to a request for comment.?

The Associated Press contributed to this report.?

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Credit Card Debt Settlement: Searching For Personal Finance ...

Keep track of what is happening in the world to keep abreast of market shifts on a global scale. Americans tend to ignore news from outside the U.S. but this is a mistake when trading currencies. If you are aware about what is happening in the world, you can improve your strategies and make more educated predications about the stock market.

You can save a lot of money by cutting your own hair and your family?s hair as well. While you might not be as good as a professional, the money you save will be worth the small reduction in quality. It is free to cut your own hair!

In order to get the most out of the property that you own, take steps to control the cash flow in to and out of it. Track the value of your home, and look at your home as a long term investment. Make sure to have your budget in control at the end of the month and use it as a guide for future months.

Make sure you are aware of when you should file income taxes. You should aim to file as early as possible in order to get your refund faster if you think you will be getting one. If you owe the government money it?s better to just file near the date they?re due which is April 15th.

The first step to credit repair is to get out of debt. You must cut back on your spending, save some money and pay off your loan and credit card debts. There are a variety of ways to save money, like making your own meals. Taking your own lunch to work and not eating out on weekends can save you a lot of money. If you?re serious about repairing your credit, you?ll have to commit to reducing your spending.

Instead of using a single maxed-out credit card, aim to use two or even more cards. Multiple card interest should be lower than paying back the maxed out one. Also, this won?t damage your score and it could also help you in building it if you could manage two credit cards wisely.

To be aware of how your money is spent, track all of your expenses during a set time period. Knowing where you are spending your money may help you see where you are overspending. This can also keep you accountable so you don?t spend too much on unneeded items.

Pay off the debt you have and stop taking on new debt. It is easy, even though we are all taught differently. It is important to not take on any extra debt while paying off your debt. You will be debt-free and gain more financial flexibility by making consistent payments.

How you view your finances should have drastically changed with the help of this article. The tips you?ve read will be able to guide you towards financial stability. All that you need to do now is actually do it, financial freedom is right around the corner!

Brad Allen

Brad Allen is a credit card debt settlement industry insider. He manages a team of credit card mediators which works directly with every major credit card issuers and collectors.

Brad charges no up front costs for this assistance on his web site http://creditcarddebtsettlementinfo.com


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Marketing For Small Business - Creativity And Innovation Driving ...

Harness the Power of Social Media for Marketing Your Small Business

Small business marketing is the process of promoting your small business in various traditional and online venues. There are many ways on how you can market your small business. These include search engine marketing, article marketing, email marketing, sponsored newsletters, sponsored emails, sponsored websites, direct mail, local and yellow pages, radio and television ads, billboard ads, mobile ads, coupon books and magazine advertising. For this article however, we are going to focus on social media marketing. This marketing technique involves the utilization of social networking and bookmarking sites to promote your business. Social media sites are among the biggest properties online, so it's not surprising that marketing through them has exponentially grown in popularity through the years. Now, there are all sorts of tools and resources that you can use to tap the social media market.

Using social media for small business marketing is, however, not as simple as you might think. You can't just sign up with a network and assume that you are good to go. A piece of advice ? before you jump into a social network, you should make sure that you will have the time to actually use and be active in it. There is no point in joining a social network if you aren't going to utilize it for what it is worth. So many business owners make the mistake of signing up with every network that they come across. This is great if you actually use them, but it's a waste of time if you don't use them. With that said, it is recommended that you should focus all your efforts on just a few networks. This way, you will have the chance of using them for their full potential. You will have the time to really use the tools and resources that the social networks offer. Quick Tip: You must spend at least five hours a week on each social network to get good ROI.

Now, since so many of the social networks today are for personal uses, it's best that you find a network that is appropriate for your small business. We are talking about business networks here. Small business marketing will be a lot more effective if you make use of a business network. A perfect example of a business network is oGoing. This is a social networking site created with small businesses in mind; so everything you need to create a social media presence for your business is provided by oGoing. The limitations that you find on other social networking sites like Facebook, Twitter and LinkedIn are not present on oGoing. Facebook is used primarily for your personal contacts, Twitter is used by large celebrities, politicians and brands, and LinkedIn is primarily used by career professionals. oGoing has real features and services that help small business owners and entrepreneurs maximize their marketing efforts. And it's totally free to use, so you have nothing to lose in joining. It's the perfect platform for small business marketing.

Interested in learning more about oGoing Small Business Social Network? Go here

Ready to get started with marketing for your small business on oGoing? Join Now

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Polish Architects Build Stereotype-Reinforcing Upside-Down House [Video]

With a last name like Liszewski, I've heard every single Polish joke and stereotype there is. But I'm going to assume that Polish architects Irek Glowacki and Marek Rozanski have just spawned at least one more with this unique tourist attraction they built in Austria. More »


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Learn About Currency Diversification | Free Finance Articles

Forex is an amazing market full of untapped profits waiting for your investment. It is a large subject with tips, trading, and tabulations! Currency trading is very competitive, and it may take a while to find what methods are best for you. Use the ideas below to help you get started.

Dabbling in a lot of different currencies is a temptation when you are still a novice forex trader. Try using one currency pair to learn the ropes. You can increase the number of pairs you trade as you gain more experience. In this way, you can prevent any substantial losses.

Fibonacci levels are an important aspect of Forex trading. Fibonacci levels give calculations and numbers that can help you in deciding when to trade. In addition, they can be an essential aid in knowing when to get out.

Avoid forex robots and ebooks like the plague if they have any language that claims to have a system that will make you very rich. The vast majority of these particular products give you methods that are untested and unproven in regards to Forex trading. The authors make their money from selling these products, not through Forex trading. Instead of wasting money on possibly dubious products, spend that initial amount of money on a Forex trader who can teach you what you need to know.

Pay attention to what is on the news, especially in the financial world, including the currencies you are trading. Speculation fuels the fluctuations in the currency market, and the news drives speculation. Set it up so that you get email and text alerts about the markets you dabble in so that you can potentially capitalize on major developments with lightning speed.

Select an account based on what your goals are and what you know about trading. It?s important to accept your limits and work within them. You will not become a professional trader overnight. It is generally accepted that a lower leverage is better in regards to account types. To reduce risks when you are starting out, a practice account is ideal. Work your way up slowly to bigger and bigger trades as you become accustomed to world of forex trading.

Get more information about other subject of interest at this website.

You are now better prepared to succeed at currency trading. If you thought you were ready earlier, now you can see that there is no limit to how much you can learn about forex trading. The tips in this article contain enough information to get you started in currency trading, and if you paid attention, you?ll be a sure success in no time.

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Video: The Future of TV

As the internet becomes more and more of a player in television, the biggest names in the business are preparing for a whole new media world, reports CNBC's Julia Boorstin.

Related Links:

Business & financial news headlines from msnbc.com

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L.E.N.S.(Lifestyle, Events, News, and Society)blogs: DepEd ...

?We are confident to say that all necessary arrangements have been secured to make this year?s Palaro truly remarkable and successful,? DepEd Secretary Br. Armin A. Luistro FSC said. The Secretary also promised a clean, green, and hi-tech Palaro this year.

DepEd tasked the National Screening and Accreditation Committee to facilitate the screening and accreditation of athletes and coaches using stricter implementation of the guidelines.

The provincial government of Pangasinan promises to provide tight security inside and outside the Palaro venues. A security officer will be assigned in every billeting quarter to monitor and ensure the safety of Palaro delegates.

Pangasinan Governor Amado Espino has also assigned a medical team from local hospitals to look after the athletes during the sports competitions.

As part of the preparations for the major sporting event, the provincial government of Pangasinan has partnered with DepEd in launching the new website for the 2012 Palaro. The new website boasts of its high functionality and uniqueness and promises to deliver the ?most digital? coverage in the history of Palaro,.

It features individual sports channels for 17 sports categories for live streaming with real time scoring and replays of the games. The Palaro 2012 TV will also be launched to showcase extraordinary stories of athletes and their journey at the Palaro, messages from guests, and other interesting stories.

The Palaro will use the breakthrough Social Media Command Center for faster response to queries and suggestions. The command center will serve as the central network of connection among participants and officials.

DepEd has also partnered with social news network Rappler as its official social media partner. Updates may be viewed via http://www.rappler.com/sports/palarong-pambansa-2012

Organizers are aiming for Palarong Pambansa to trend worldwide on twitter for the duration of the games by using #palaro2012 for all Palaro related updates.

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